Propranolol Cardiovascular: MedlinePlus Drug Information

In a study of 9 healthy women and 12 healthy men, neither the administration of testosterone nor the regular course of the menstrual cycle affected the plasma binding of the propranolol enantiomers. In contrast, there was a significant, although non-enantioselective diminution of the binding of propranolol after treatment with ethinyl estradiol. In women, none of the metabolic clearances for propranolol showed any significant association with either bromism wikipedia estradiol or testosterone. Clearance of propranolol is reduced with aging due to decline in oxidation capacity (ring oxidation and side-chain oxidation). No correlation was found between age and the partial metabolic clearance to propranolol glucuronide (PPLG-conjugation). In a study of 12 elderly (62-79 years old) and 12 young (25-33 years old) healthy subjects, the clearance of S(-)-enantiomer of propranolol was decreased in the elderly.

  1. Inderide is not indicated for the treatment of hypertensive emergencies.
  2. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
  3. Note that this list is not all-inclusive and includes only common medications that may interact with propranolol.
  4. Tell any doctor who treats you that you are using propranolol.

A person should discuss all medications, supplements, and other substances they take with their doctor. Their doctor can help determine if there are alternatives or can advise a person to stop taking other medications if needed. In other words, the person’s emotional attachment to the negative memory may not be as strong while taking propranolol. This could help people manage a negative emotional memory or traumatic event. Negative emotions play a role in mental health conditions such as post-traumatic stress disorder (PTSD).

These make your heart rate faster and make you sweat or shake. Propranolol helps block the effects of these chemical messengers. Propranolol, as well as other beta blockers, has been shown in some studies to reduce your body’s secretion of melatonin — an important hormone for optimal sleep. For a small percentage of propranolol users, this can lead to difficulties falling — and staying—asleep.

Alcohol may interfere with the effect of this medication. Have your blood pressure and pulse checked regularly while taking this medication. It may be best to learn how to monitor your own blood pressure and pulse. Examples of drugs that can cause interactions with propranolol are listed below. Propranolol belongs to a group of drugs called beta-blockers. If you get severe headaches, there are steps you can take to help prevent migraines.

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription. If you’re having problems with your sex life, talk to your doctor. Some substance use disorder sud people on propranolol say their sex drive goes down and some men find they cannot get an erection. However, this is not a common side effect and there is not enough evidence to say for sure that propranolol is causing it.

What may interact with this medication?

Your very first dose of propranolol may make you feel dizzy, so take it at bedtime. After that, if you do not feel dizzy, you can take it in the morning. The main side effects of propranolol are feeling dizzy or tired, cold hands or feet, difficulties sleeping and nightmares. Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine. You may report side effects to FDA at FDA-1088 or at /medwatch.

What should I watch for while using this medication?

RxList does not provide medical advice, diagnosis or treatment. This medicine may increase risk of stroke in PHACE syndrome patients with severe blood vessel problems in the brain. Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine.

Caution is advised if you have alcohol dependence or liver disease. Ask your doctor or pharmacist about using this product safely. If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take propranolol at least 1 hour before or at least 4 hours after these medications. If you have high blood pressure, keep using this medicine even if you feel well. Your heart function and blood pressure will need to be checked often. Hemangeol can cause low blood sugar (hypoglycemia), especially during times of stress, illness, infections, or skipped meals.

Drinking alcohol can increase the blood pressure-lowering effect of propranolol, which can make you feel dizzy or lightheaded. There are some other medicines that are known to prevent migraines but they are not officially approved in the UK. They include amitriptyline, sodium valproate and gabapentin and they may have different side effects. Beta blockers, sometimes used for hypertension and heart irregularities, such as propranolol and atenolol. Statins can rarely cause brain fog, but on the other hand they lower high cholesterol that left untreated raises the risk of dementia. Depression and anxiety can cause sleep, thinking and memory difficulties.

Can You Reset Your Heart Rhythm?

Inderal is indicated to decrease angina frequency and increase exercise tolerance in patients with angina pectoris. You are encouraged to report negative side effects of prescription drugs to the FDA. Along with its needed effects, a medicine may cause some unwanted effects.

As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart. Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective. One study of 34 hypertensive patients who were taking propranolol found the incidence of depressive symptoms in this population to be 50% to 74% (depending on the criteria used). Propranolol-induced depression may be more likely in patients with a personal or family history of depression.

If your doctor decides you should no longer use this drug, you must gradually decrease your dose according to your doctor’s instructions. provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated 3 Mar 2024), Cerner Multum™ (updated 17 Mar 2024), ASHP (updated 20 Mar 2024) and others. Studies have reported a delayed absorption rate and a reduced half-life of propranolol in patients with renal failure of varying severity.

Lowering blood pressure may reduce the risk of stroke and heart attacks. Propranolol is a beta-blocker used to treat high blood pressure, irregular heartbeats, shaking (tremors), and other conditions. Preventing chest pain can help improve your ability to exercise. Propranolol tablets (Inderal®) are a beta-blocker medication that works by lowering your blood pressure and heart rate, making it easier for your heart to pump blood.

Before taking propranolol, tell your doctor or pharmacist if you are allergic to it; or if you have had a serious reaction to other beta blockers (such as metoprolol); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Immediate-release propranolol will clear out of your body in about 1 to 2 days after your last dose, but the therapeutic effects may only last about 8 to 12 hours. The half-life of propranolol (the time it takes for its blood concentration to reduce by one-half) is about 3 to 6 hours.

In this case, just leave out the missed dose and take your next dose at the usual time. If you’re taking propranolol as a liquid, it will come with a plastic syringe or spoon to help you measure out the right dose. Do not use a kitchen teaspoon as it will not measure the right amount of medicine.

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